Piroctone Olamine (CAS:68890-66-4)

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CAS No.:68890-66-4

English name:Piroctone Oleamine, PIROCTONE OLAMINE(P.O)

Structural formula:Pyridone-ethanolamine-salt-3

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PO products have excellent anti-dandruff and anti-itching effects, unique anti-dandruff mechanism, excellent solubility and recombination, safety, non-toxic, non-irritating, and are mainly used in shampoo and hair care products. PO has excellent antipruritic effects, and also has sterilization and deodorization functions, so it has been used in bath lotions to achieve good results. PO has a broad-spectrum killing effect on fungi and molds, and has a good therapeutic effect on foot and hand ringworm. It can be used as a preservative in cosmetics, as a bactericide in soap, and as a thickening agent. Therefore, PO is a multifunctional anti-dandruff and antipruritic bactericide, which is widely used in shampoo and hair care products, bath lotions, cosmetics, and detergents.

Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria[1]. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL).

This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05)

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